Losartan occurs as drug utilized to address high blood pressure (hypertension) and has been examined for congestive heart failure and diabetic nephropathy. These are marketed when Cozaar® by Merck Sharp and Dohme and as Hyzaar® in combination by owning a thiazide diuretic hydrochlorothiazide (HCT).

Losartan was a foremost member of the recently introduced class of angiotensin II receptor antagonists. It bars a action of the peptide hormone angiotensin on its receptors, decreasing arterial vascular tone and production of aldosterone.

Indications:

Essential hypertension Hypertension with left ventricular hypertrophy for lowering the chance of cardiovascular morbidity and mortality Diabetes mellitus type 2 with proteinuria for slowing down the progression of kidney disease

Because of proved effectualness & moo costs, a 1st guide of drug for essential hypertension occurs as thiazide or beta blocker. A primary have of angiotensin II receptor antagonists is as a replacement for ACE inhibitors when the patient suffers of the lasting dry cough as a side effect of the ACE inhibitor.

Adverse effects

Adverse results of Losartan include: Dizziness Hyperkalemia

Overdose

An overdose of losartan might symptom within hypotension and tachycardia.

Availability

Within virtually all countries, this medication is available merely by prescription.